María Arroyo-Hernández

Juan José Uriarte
Beatriz L. Rodilla
Víctor Martín- Domínguez

• Funcionalización superficial para el desarrollo de nuevos materiales biocompatibles.
• Desarrollo de recubrimientos y estructuras tridimensionales biocompatibles.
• Fabricación de sensores para señales biológicas en sistemas in-vitro.

La investigación del grupo va en la línea de desarrollar nuevos materiales, mediante crecimiento y modificación superficial de materiales ya existentes y la creación de estructuras tridimensionales. En todos los casos, se busca optimizar las propiedades de biocompatibilidad para su uso en aplicaciones clínicas como prótesis o medicina regenerativa. De modo simultáneo, se busca disminuir el crecimiento bacteriano y la formación de biofilm sobre las mismas.

Raúl Gago del Instituto de Ciencia de Materiales de Madrid del CSIC.

Texturization of polycrystalline titanium surfaces after low-energy ion-beam irradiation: Impact on biocompatibility M.A. Garcia, R. Gago, M. Arroyo-Hernández, E.H. de Laorden, M. Iglesias, D. Esteban-Mendoza, R. Cuerno e, J. Rickards. Surface and Coatings Technology. Volume 458, 15. https://doi.org/10.1016/j.surfcoat.2023.129363

Stability and activity of lactate dehydrogenase on biofunctional layers deposited by activated vapor silanization (AVS) and immersion silanization (IS). Jorge Nieto-Márquez Calvo, Manuel Elices, Gustavo V Guinea, José Pérez-Rigueiro, María Arroyo-Hernández. Applied Surface Science, 416, 965-970

Comparison of cell mechanical measurements provided by Atomic Force Microscopy (AFM) and Micropipette Aspiration (MPA). Rafael Daza, Blanca González-Bermúdez, Julia Cruces, Mónica De la Fuente, Gustavo R Plaza, María Arroyo-Hernández, Manuel Elices, José Pérez-Rigueiro, Gustavo V Guinea. Journal of the mechanical behavior of biomedical materials, 95, 103-115.

Development of a versatile procedure for the biofunctionalization of Ti-6Al-4V implants. Parsa Rezvanian, María Arroyo-Hernández, Milagros Ramos, Rafael Daza, Manuel Elices, Gustavo V Guinea, José Pérez-Rigueiro. Applied Surface Science, 387, 652-660

Human alveolar hydrogels promote morphological and transcriptional differentiation in iPSC-derived alveolar type 2 epithelial cells. Hoffman ET, Uriarte JJ, Uhl FE, Eckstrom K, Tanneberger AE, Becker C, Moulin C, Asarian L, Ikonomou L, Kotton DN, Weiss DJ. Sci Rep. 2023 Jul 25;13(1):12057. doi: 10.1038/s41598-023-37685-x.

Decellularization and Recellularization Methods for Avian Lungs: An Alternative Approach for Use in Pulmonary Therapeutics. Tanneberger AE, Weiss DJ, Uriarte JJ. Methods Mol Biol. 2022;2394:617-649. doi: 10.1007/978-1-0716-1811-0_33.

Development of alginate and gelatin-based pleural and tracheal sealants. Gasek N, Park HE, Uriarte JJ, Uhl FE, Pouliot RA, Riveron A, Moss T, Phillips Z, Louie J, Sharma I, Mohammed B, Dearborn J, Lee PC, Jensen T, Garner J, Finck C, Weiss DJ. Acta Biomater. 2021 Sep 1;131:222-235. doi: 10.1016/j.actbio.2021.06.048. Epub 2021 Jul 7.

Functional role of glycosaminoglycans in decellularized lung extracellular matrix. Uhl FE, Zhang F, Pouliot RA, Uriarte JJ, Rolandsson Enes S, Han X, Ouyang Y, Xia K, Westergren-Thorsson G, Malmström A, Hallgren O, Linhardt RJ, Weiss DJ. Acta Biomater. 2020 Jan 15;102:231-246. doi: 10.1016/j.actbio.2019.11.029. Epub 2019 Nov 18.

Biomechanical Response of Lung Epithelial Cells to Iron Oxide and Titanium Dioxide Nanoparticles. Oliveira VR, Uriarte JJ, Falcones B, Jorba I, Zin WA, Farré R, Navajas D, Almendros I. Front Physiol. 2019 Aug 16;10:1047. doi: 10.3389/fphys.2019.01047. eCollection 2019.

Claudia Fernández-González; Alejandra Guedeja-Marrón; Beatriz L. Rodilla; Ana Arché-Núñez; Rubén Corcuera;  Irene Lucas; M. Teresa González; María Varela; Patricia de la Presa; Lucía Aballe; Lucas Pérez; Sandra Ruiz-Gómez. Electrodeposited Magnetic Nanowires with Radial Modulation of Composition. Nanomaterials. 12 -2565, 2022. DOI: 10.3390/nano12152565

Ana Domínguez‐Bajo; Juliana M. Rosa; Ankor González‐Mayorga; Beatriz L. Rodilla; Ana Arché‐Núñez; Esther Benayas; Pilar Ocón; Lucas Pérez; Julio Camarero; Rodolfo Miranda; Marí Teresa González; Juan Aguilar; Elisa López-Dolado; María C. Serrano. Nanostructured gold electrodes promote neural maturation and network connectivity. Biomaterials. 121186, 2021. DOI: 10.1016/j.biomaterials.2021.121186

Ivo Calaresu; Jaime Hernández; Rossana Rauti; Beatriz L. Rodilla; Ana Arché‐Núñez; Lucas Pérez; Julio Camarero; Rodolfo Miranda; María Teresa González; Isabel Rodríguez; Denis Scaini; Laura Ballerini. Polystyrene Nanopillars with Inbuilt Carbon Nanotubes Enable Synaptic Modulation and Stimulation in Interfaced Neuronal Networks. Adv. Mater. Interfaces. 2002121, 2021. DOI: 10.1002/admi.202002121

Ana Domínguez‐Bajo; Beatriz L. Rodilla, Ivo Calaresu; Ana Arché‐Núñez; Ankor González‐Mayorga; Denis Scaini; Lucas Pérez; Julio Camarero; Rodolfo Miranda; Elisa López‐Dolado; María Teresa González; Laura Ballerini; María Concepción Serrano. Interfacing Neurons with Nanostructured Electrodes Modulates Synaptic Circuit Features. Advanced Biosystems. 4 – 9, 2020. DOI: 10.1002/adbi.202000117

Martin-Dominguez, V.; Garcia-Montalvo, J.; Garcia-Martin, A.; Ladero, M.; Santos, V.E. Fumaric Acid Production by R. arrhizus NRRL 1526 Using Apple Pomace Enzymatic Hydrolysates: Kinetic Modelling. Processes 2022, 10, 2624. https:// doi.org/10.3390/pr1012262

Victor Martin-Dominguez, Laura Bouzas-Santiso, Nieves Martinez-Peinado, Victoria E. Santos and Miguel Ladero. Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526. Processes 2020, 8, 188; doi:10.3390/pr8020188

Martin-Dominguez, V.; Cabrera, P.I.A.; Eidt, L.; Pruesse, U.; Kuenz, A.; Ladero, M.; Santos, V.E. Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess. Fermentation 2022, 8, 64. https://doi.org/10.3390/fermentation8020064