NEUROSCIENCE RESEARCH GROUPS
NEUROREHABILITATION OF BRAIN INJURY AND MOVEMENT DISORDERS RESEARCH GROUP
STAFF
PRINCIPAL INVESTIGATOR:
Dr. Juan Pablo Romero Muñoz p.romero.prof@ufv.es
CONTRACTED RESEARCHERS:
PREDOCTORAL CONTRACTED RESEARCHERS
Francisco José Sánchez Cuesta (Physiotherapist) fjose.sanchez@ufv.es fjose.sanchez@ufv.es
Yeray Gonzalez Zamorano y.gonzalezz@alumnos.urjc.es y.gonzalezz@alumnos.urjc.es
Laura Valenzuela López laura.valenzuela@ufv.es
POSTDOCTORAL SENIOR ASSOCIATE RESEARCHERS
Ana María Maitín (Physics) a.maitin@ceiec.es a.maitin@ceiec.es
Arroyo Ferrer (Neuropsychologist) 7890001@alumnos.ufv.es
COLLABORATING RESEARCHERS AT BEATA MARÍA ANA HOSPITAL:
Marcos Ríos PhD. Neuropsychologist Ana Bravo MD. Internist Paulina Oliva MD. Rehabilitation Physician Paloma Fernandez Physiotherapist
FOR COMPLETE INFORMATION ON THE RESEARCH LINES OF THE GROUP, PLEASE CLICK ON THE FOLLOWING LINK:
https://www.ufv.es/neurorrehabilitacion-dano-cerebral/
RESEARCH TEAMS WITH STABLE COLLABORATIONS:
Computational Biophysics Group UFV Neural and Cognitive Engineering Group (GNEC) 12 de Octubre Hospital Neuroscience Group Laboratory of Medical Imagining and biometric analysis (LAMBIO) Universidad Rey Juan Carlos Facultad de Fisioterapia Biomedical Ingeneering Lab- Politecnico Lisboa www.laseeb.org
www.laseeb.org
STUDENTS
PREGRADUATE STUDENTS (TFG)
Olivia Romera (2020) Janet Fernández (2020) Antonio Pérez (2020) Pablo Espáriz (2019) Macarena Casas (2018) Rosa García (2018)
POSTGRADUATE STUDENTS (Master)
Jorge Andreo (2017-2019)
POSTGRADUATE STUDENTS (PhD)
Alfredo Traba (2015-2018) Aida Arroyo Ferrer (2018-) Francisco José Sánchez Cuesta (2020-) Ana María Maitín (2019-) Juan José García Nuria Serradell (collaboration UOC) (2019-) Yeray González Zamorano (2021-) Yeray González Zamorano (2021-) POSTGRADUATE STUDENTS (Doctoral) ) Ana María Maitín(2019-) Juan José García Nuria Serradell (UOC collaboration) (2019-) Yeray González Zamorano (2021-)
RESEARCH LINES
- Neurorehabilitation of motor and cognitive symptoms of Parkinson’s disease
- Motor and cognitive neurorehabilitation of the sequelae of acquired brain injury
BIOSANITARY RESEARCH INSTITUTE
Biosanitary Research Institute
Building E, 9 a.m. to 2 p.m. Monday to Friday
RESEARCH SUMMARY
The aim of the group is to develop a line that covers neurorehabilitation of neurological pathologies using the most advanced technology available. Based on clinical and therapeutic needs, a direct translation is made by collaborating with robotic engineering groups such as the GNEC of CSIC or engineers specializing in image processing in post-processing as the URJC.
The active projects of the group are oriented towards non-invasive neuromodulation for neurorehabilitation of both the sequelae of acquired brain damage (stroke or TBI) and Parkinson’s disease.
Brain neuromodulation attempts to change the electrical and functional behavior of neuronal networks that are altered, enhancing their normal functioning. We use the following techniques:
- Transcranial magnetic stimulation, which seeks to change the excitability of the cerebral cortex using electromagnetic energy applied externally, without causing any discomfort to the patient.
- Transcranial electrical stimulation by direct current, which seeks to change the excitability of the cerebral cortex using direct electrical energy applied transcranially with either high or low definition.
- Endogenous neuromodulation with the use of immersive 3D EEG-powered system that allows us to teach patients to “retrain” their brain rhythms to enhance the effects of conventional rehabilitation.
In addition to these techniques we participate in the validation of exoprostheses or devices designed to support the rehabilitation or diagnosis of motor or non-motor disorders.
A newer line of our study is the neuropsychological and posturographic study of Parkinson’s disease which is currently in its initial phase.
The purpose of our research lines is to make available to patients an effective and non-invasive technique at hospital level (magnetic stimulation, electrical stimulation and neurofeedback) that can be complemented with conventional therapies reducing health costs, improving their welfare and potentially reducing their requirements for medication.
This activity puts our university on the map of clinical research in Neurology and allows us to form research links with numerous groups dedicated to this type of neurophysiological research around the world. Cortical neurophysiology research is one of the Hot Topics of the last years.
The group is open to collaborations with students, professors and other researchers inside and outside the university interested in this line of research.
PUBLICATIONS last five years
Gurdiel-Álvarez F, González-Zamorano Y, Lerma Lara S, Gómez-Soriano J, Taylor J, Romero JP, et al. Effectiveness of Unihemispheric Concurrent Dual-Site Stimulation over M1 and Dorsolateral Prefrontal Cortex Stimulation on Pain Processing: A Triple Blind Cross-Over Control Trial. Brain Sciences. febrero de 2021;11(2):188.
Arroyo-Ferrer A, Sánchez-Cuesta FJ, González-Zamorano Y, Del Castillo MD, Sastre-Barrios C, Ríos-Lago M, et al. Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients with Parkinson’s Disease: Study Protocol for a Randomized Controlled Trial. Medicina (Kaunas). 26 de marzo de 2021;57(4).
Romero JP, Bravo-Martín A, Oliva-Navarrete P, Sánchez-Cuesta F, Ríos-Lago M, Benito-León J. Impact of COVID-19 on a brain damage unit. Diabetes & Metabolic Syndrome: Clinical Research & Reviews [Internet]. 6 de junio de 2021 [citado 7 de junio de 2021]; Disponible en: https://www.sciencedirect.com/science/article/pii/S1871402121001818
Aida Arroyo-Ferrer D de N, Aida Arroyo-Ferrer D de N. Cognitive rehabilitation in a case of traumatic brain injury using EEG-based neurofeedback in comparison to conventional methods. Journal of Integrative Neuroscience. 30 de junio de 2021;20(2):449-57.
Arroyo-Ferrer A, Andreo J, Periáñez JA, Ríos-Lago M, Lubrini G, Herreros-Rodríguez J, et al. Computerized Simple Reaction Time and Balance in Nondemented Parkinson’s Patients. NDD. 16 de julio de 2021;1-7.
Sánchez-Cuesta FJ, Arroyo-Ferrer A, González-Zamorano Y, Vourvopoulos A, Badia SB i, Figuereido P, et al. Clinical Effects of Immersive Multimodal BCI-VR Training after Bilateral Neuromodulation with rTMS on Upper Limb Motor Recovery after Stroke. A Study Protocol for a Randomized Controlled Trial. Medicina. agosto de 2021;57(8):736.
Maitín AM, García-Tejedor AJ, Muñoz JPR. Machine Learning Approaches for Detecting Parkinson’s Disease from EEG Analysis: A Systematic Review. Applied Sciences. enero de 2020;10(23):8662.
González-Zamorano Y, Fernández-Carnero J, Sánchez-Cuesta FJ, Arroyo-Ferrer A, Vourvopoulos A, Figueiredo P, et al. New Approaches Based on Non-Invasive Brain Stimulation and Mental Representation Techniques Targeting Pain in Parkinson’s Disease Patients: Two Study Protocols for Two Randomized Controlled Trials. Brain Sciences. enero de 2021;11(1):65.
Maitín AM, Perezzan R, Herráez-Aguilar D, Serrano JI, Del Castillo MD, Arroyo A, et al. Time Series Analysis Applied to EEG Shows Increased Global Connectivity during Motor Activation Detected in PD Patients Compared to Controls. Applied Sciences. enero de 2021;11(1):15.
Arroyo A, Periáñez JA, Ríos‐Lago M, Lubrini G, Andreo J, Benito‐León J, et al. Components determining the slowness of information processing in parkinson’s disease. Brain and Behavior. 2021 (n/a):e02031.
Benito-León, Julián, Elan D. Louis, Eva Manzanedo, Juan Antonio Hernández-Tamames, Juan Álvarez-Linera, José Antonio Molina-Arjona, Michele Matarazzo, et al. «Resting State Functional MRI Reveals Abnormal Network Connectivity in Orthostatic Tremor». Medicine 95, n.o 29 (julio de 2016): e4310. https://doi.org/10.1097/MD.0000000000004310.
Benito-León, Julián, Elan D. Louis, Virginia Mato-Abad, Ulrike Dydak, Juan Álvarez-Linera, Juan Antonio Hernández-Tamames, José Antonio Molina-Arjona, et al. «In Vivo Neurometabolic Profiling in Orthostatic Tremor». Medicine 95, n.o 37 (septiembre de 2016): e4848. https://doi.org/10.1097/MD.0000000000004848.
Benito-León, Julián, Elan D. Louis, Virginia Mato-Abad, Alvaro Sánchez-Ferro, Juan P. Romero, Michele Matarazzo, y J. Ignacio Serrano. «A Data Mining Approach for Classification of Orthostatic and Essential Tremor Based on MRI-Derived Brain Volume and Cortical Thickness». Annals of Clinical and Translational Neurology 6, n.o 12 (diciembre de 2019): 2531-43. https://doi.org/10.1002/acn3.50947.
Benito-León, Julián, Elan D. Louis, Verónica Puertas-Martín, Juan Pablo Romero, Michele Matarazzo, José Antonio Molina-Arjona, Cristina Domínguez-González, y Álvaro Sánchez-Ferro. «Cognitive and Neuropsychiatric Features of Orthostatic Tremor: A Case-Control Comparison». Journal of the Neurological Sciences 361 (15 de febrero de 2016): 137-43. https://doi.org/10.1016/j.jns.2015.12.031.
Benito-León, Julián, Elan D. Louis, Juan Pablo Romero, Juan Antonio Hernández-Tamames, Eva Manzanedo, Juan Álvarez-Linera, Félix Bermejo-Pareja, Ignacio Posada, y Eduardo Rocon. «Altered Functional Connectivity in Essential Tremor: A Resting-State FMRI Study». Medicine 94, n.o 49 (diciembre de 2015): e1936. https://doi.org/10.1097/MD.0000000000001936.
Benito-León, Julián, Virginia Mato-Abad, Elan D. Louis, Juan Antonio Hernández-Tamames, Juan Álvarez-Linera, Félix Bermejo-Pareja, Ángela Domingo-Santos, Luis Collado, y Juan Pablo Romero. «Author Correction: White Matter Microstructural Changes Are Related to Cognitive Dysfunction in Essential Tremor». Scientific Reports 8, n.o 1 (6 de marzo de 2018): 4301. https://doi.org/10.1038/s41598-018-22516-1.
«White matter microstructural changes are related to cognitive dysfunction in essential tremor». Scientific Reports 7 (7 de junio de 2017). https://doi.org/10.1038/s41598-017-02596-1.
Benito‐León, Julián, Juan P. Romero, Elan D. Louis, Alvaro Sánchez‐Ferro, Michele Matarazzo, José A. Molina‐Arjona, y Virginia Mato‐Abad. «Diffusion Tensor Imaging in Orthostatic Tremor: A Tract-Based Spatial Statistics Study». Annals of Clinical and Translational Neurology 6, n.o 11 (2019): 2212-22. https://doi.org/10.1002/acn3.50916.
Benito-León, Julián, Juan P. Romero, Elan D. Louis, Alvaro Sánchez-Ferro, Michele Matarazzo, José A. Molina-Arjona, y Virginia Mato-Abad. «Diffusion Tensor Imaging in Orthostatic Tremor: A Tract-Based Spatial Statistics Study». Annals of Clinical and Translational Neurology 6, n.o 11 (noviembre de 2019): 2212-22. https://doi.org/10.1002/acn3.50916.
Benito-León, Julián, Emilio Sanz-Morales, Helena Melero, Elan D. Louis, Juan P. Romero, Eduardo Rocon, y Norberto Malpica. «Graph Theory Analysis of Resting-State Functional Magnetic Resonance Imaging in Essential Tremor». Human Brain Mapping 40, n.o 16 (01 de 2019): 4686-4702. https://doi.org/10.1002/hbm.24730.
«Graph Theory Analysis of Resting-State Functional Magnetic Resonance Imaging in Essential Tremor». Human Brain Mapping, 22 de julio de 2019. https://doi.org/10.1002/hbm.24730.
Benito-León, Julián, J. Ignacio Serrano, Elan D. Louis, Ales Holobar, Juan P. Romero, P. Povalej-Bržan, Félix Bermejo-Pareja, M. Dolores Del Castillo, Ignacio J. Posada, y Eduardo Rocon. «Tremor Severity in Parkinson’s Disease and Cortical Changes of Areas Controlling Movement Sequencing: A Preliminary Study». Journal of Neuroscience Research, 16 de abril de 2018. https://doi.org/10.1002/jnr.24248.
Benito‐León, Julián, José Ignacio Serrano, Elan D. Louis, Ales Holobar, Juan P. Romero, Petra Povalej‐Bržan, Jernej Kranjec, et al. «Essential Tremor Severity and Anatomical Changes in Brain Areas Controlling Movement Sequencing». Annals of Clinical and Translational Neurology 0, n.o 0 (s. f.). https://doi.org/10.1002/acn3.681.
Gallego, Juan A., Jakob L. Dideriksen, Ales Holobar, Jaime Ibáñez, Vojko Glaser, Juan P. Romero, Julián Benito-León, José L. Pons, Eduardo Rocon, y Dario Farina. «The Phase Difference Between Neural Drives to Antagonist Muscles in Essential Tremor Is Associated with the Relative Strength of Supraspinal and Afferent Input». The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 35, n.o 23 (10 de junio de 2015): 8925-37. https://doi.org/10.1523/JNEUROSCI.0106-15.2015.
Holobar, Aleš, Juan A. Gallego, Jernej Kranjec, Eduardo Rocon, Juan P. Romero, Julián Benito-León, José L. Pons, y Vojko Glaser. «Motor Unit-Driven Identification of Pathological Tremor in Electroencephalograms». Frontiers in Neurology 9 (29 de octubre de 2018). https://doi.org/10.3389/fneur.2018.00879.
López-Blanco, R., J. Benito-León, S. Llamas-Velasco, M. D. Del Castillo, J. I. Serrano, E. Rocon, J. P. Romero, y M. A. Velasco. «Interaction with Touchscreen Smartphones in Patients with Essential Tremor and Healthy Individuals». Neurologia (Barcelona, Spain), 10 de agosto de 2018. https://doi.org/10.1016/j.nrl.2018.05.005.
López-Blanco, Roberto, Miguel A. Velasco, Antonio Méndez-Guerrero, Juan Pablo Romero, María Dolores Del Castillo, J. Ignacio Serrano, Julián Benito-León, Félix Bermejo-Pareja, y Eduardo Rocon. «Essential Tremor Quantification Based on the Combined Use of a Smartphone and a Smartwatch: The NetMD Study». Journal of Neuroscience Methods, 23 de febrero de 2018. https://doi.org/10.1016/j.jneumeth.2018.02.015.
López-Blanco, Roberto, Miguel A. Velasco, Antonio Méndez-Guerrero, Juan Pablo Romero, María Dolores Del Castillo, J. Ignacio Serrano, Eduardo Rocon, y Julián Benito-León. «Smartwatch for the Analysis of Rest Tremor in Patients with Parkinson’s Disease». Journal of the Neurological Sciences 401 (15 de junio de 2019): 37-42. https://doi.org/10.1016/j.jns.2019.04.011.
Puertas-Martín, Verónica, Alberto Villarejo-Galende, Sara Fernández-Guinea, Juan Pablo Romero, Elan D. Louis, y Julián Benito-León. «A Comparison Study of Cognitive and Neuropsychiatric Features of Essential Tremor and Parkinson’s Disease». Tremor and Other Hyperkinetic Movements 6 (15 de diciembre de 2016). https://doi.org/10.7916/D86H4HRN.
Serrano, J. Ignacio, María Dolores del Castillo, Verónica Cortés, Nuno Mendes, Aida Arroyo, Jorge Andreo, Eduardo Rocon, María del Valle, Jaime Herreros, y Juan Pablo Romero. «EEG Microstates Change in Response to Increase in Dopaminergic Stimulation in Typical Parkinson’s Disease Patients». Frontiers in Neuroscience 12 (2018). https://doi.org/10.3389/fnins.2018.00714.
Serrano, J. Ignacio, Stefan Lambrecht, M. Dolores del Castillo, Juan P. Romero, Julián Benito-León, y Eduardo Rocon. «Identification of Activities of Daily Living in Tremorous Patients Using Inertial Sensors». Expert Systems with Applications 83 (15 de octubre de 2017): 40-48. https://doi.org/10.1016/j.eswa.2017.04.032.
Serrano, J. Ignacio, Juan P. Romero, Ma Dolores del Castillo, Eduardo Rocon, Elan D. Louis, y Julián Benito-León. «A data mining approach using cortical thickness for diagnosis and characterization of essential tremor». Scientific Reports 7 (19 de mayo de 2017). https://doi.org/10.1038/s41598-017-02122-3.
Traba, Alfredo, Juan Pablo Romero, Beatriz Arranz, y Concepción Vilela. «A New Criterion for Detection of Radiculopathy Based on Motor Evoked Potentials and Intraoperative Nerve Root Monitoring». Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 129, n.o 10 (20 de julio de 2018): 2075-82. https://doi.org/10.1016/j.clinph.2018.07.005.
ACTIVE PROJECTS
Title: TDCSNeglect Use of transcranial direct current stimulation as adjuvant therapy in the rehabilitation of hemineglect in stroke
Funding entity: Universidad Francisco de Vitoria (Internal Competitive Project) Call 2020
Duration: 2 years.
Amount: €10,500
Collaborators: Cognitive Neurolab. Universidad Oberta de Catalunya http://cognitiveneurolab.org/
Title: HandBoost. Use of repetitive transcranial magnetic stimulation as adjuvant therapy in upper limb rehabilitation in cortical ischemic stroke
Funding Entity: Universidad Francisco de Vitoria (Internal Competitive Project) Call 2019
Duration: 2 years.
Amount: 6,000€
Collaborators: Grupo de Ingeniería Neural y Cognitiva CSIC. https://g-nec.car.upm-csic.es/
Title: Balanc-EP Processing speed as an evolutionary marker in Parkinson’s disease and associated balance disorders.
Funding entity: Asociación Madrileña de Neurología (Competitive Project) Call 2019
Duration: 1 year.
Amount: €5,000
Collaborators:
Title: ExoMI. Evaluation of a gait rehabilitation and support system for people with lower limb motor sequelae secondary to acquired brain injury.
Funding entity: Not funded
Duration: 3 years.
Collaborators: Grupo de Ingeniería Neural y Cognitiva CSIC. https://g-nec.car.upm-csic.es/
Cerebral Damage Unit of Hospital Beata María Ana. Madrid.
Title: EntroPark. Entropy in the electroencephalographic recording as an evolutionary marker of Parkinson’s disease and neuropsychological correlate
Funding entity: Not funded
Duration: 3 years.
Collaborators: Centro de Innovación Experimental del Conocimiento UFV https://www.ufv.es/investigacion-ufv/ceiec/ https://www.ufv.es/investigacion-ufv/ceiec/
Title: MLEEG-PD. Analysis of electroencephalograms as a marker of Parkinson’s disease using Deep Learning techniques.
Funding entity: Not funded.
Duration: 3 years.
Collaborators: Centro de Innovación Experimental del Conocimiento UFV.www.ufv.es/investigacion-ufv/ceiec/ www.ufv.es/investigacion-ufv/ceiec/
Cerebral Damage Unit of Hospital Beata María Ana. Madrid.
Neural and Cognitive Engineering Group CSIC.
Title: PainPD-tDCS. Effectiveness of transcranial direct current stimulation in the treatment of pain in patients with Parkinson’s disease.
Funding entity: Not funded.
Duration: 2 years.
Collaborators: Pain and Rehabilitation Sciences Research Group (GINDYCR) – Universidad Rey Juan Carlos.
Title: PainPD-Imagine. Action Observation Protocol with Motor Imagery through the NeuRow platform in the treatment of pain in patients with Parkinson’s Disease.
Funding entity: Not funded.
Duration: 2 years.
Collaborators: Pain and Rehabilitation Sciences Research Group (GINDYCR) – Universidad Rey Juan Carlos.
Brain Injury Unit of the Beata María Ana Hospital. Madrid.
Neural and Cognitive Engineering Group CSIC.
PROJECTS COMPLETED in the last 5 years:
Title: NeuroMOD Development and clinical validation of a neuromodulation-based rehabilitation platform for patients with motor control disorders
Funding entity: Ministry of Economy. Society Challenges Projects 2015
Duration: 3 years.
Amount: 145,000.€